This review is primarily concerned with two key issues in research on dystrophin: (1) how the protein interacts with the plasma membrane of skeletal muscle fibres and (2) how an absence of dystrophin gives rise to Duchenne muscular dystrophy. In relation to the first point, we suggest that the post‐translational acylation of dystrophin may contribute to its interaction with the plasma membrane. Regarding the second point, it is generally considered that an absence of dystrophin makes the plasma membrane susceptible to (...) damage by contraction/relaxation cycles. In this connection, we propose that the progressive nature of Duchenne dystrophy, and the phenotypic characteristics of mdx mice, are more consistent with dystrophin functioning as a mechanical transducer that transmits growth stimuli from the enlarging skeleton to the muscle. On the basis of this hypothesis, dystrophin‐deficient muscles would be unable to grow at the same rate as the skeleton. (shrink)

On 17 May 2016 Lucy Welsh interviewed Annelise Riles about her work on the relationship between law and time as part of Welsh’s involvement with the AHRC Regulating Time network. Annelise Riles is the Jack G. Clarke Professor of Law in Far East Legal Studies and Professor of Anthropology at Cornell, and is Director of the Clarke Program in East Asian Law and Culture. Her work examines the transnational dimensions of laws, markets and culture across the fields of (...) comparative law, conflict of laws, the anthropology of law, public international law and international financial regulation. Most recently Professor Riles has been examining the nature and meaning of the settlement made on the so-called Comfort Women, and what impact that has for locating events in the past. The Comfort Women were Korean women who were essentially captured and forced to work as sexual slaves for the Japanese army during World War Two. In 2015, Japanese and South Korean ministers agreed a settlement in what they regarded as an irreversible and final settlement of the issue. Welsh and Riles exchange over their mutual interests in time and routinisation in this interview as they discuss what the story of the Comfort Women has to tell us. (shrink)

That Piagetian epistemology has the dynamics of knowledge growth as its core consideration predetermines a need to consider it as potentially applicable to teaching. This paper addresses that need by first outlining the Piagetian theory of equilibration and then applying it to the construction of methods of teaching science.

Revolutions have shaped world politics for the last three hundred years. This volume shows why revolutions occur, how they unfold, and where they created democracies and dictatorships. Jack A. Goldstone presents the history of revolutions from America and France to the collapse of the Soviet Union, 'People Power' revolutions, and the Arab revolts.

This essay suggests the possible form of an orthodox historicism. The essay begins by examining the historicism of Heidegger and Gadamer. It then proposes how a theology might appear which places the faith in conversation with this historicism.

Part biography and part constructive ethical inquiry, this book is an original interpretation of the Scottish philosopher Adam Ferguson’s ethical method and view of ethical integrity, with an emphasis on his Analysis, Institutes, and Principles.

It is a great pleasure to introduce this collection of papers on the use of introspective evidence in cognitive science. Our task as guest editors has been tremendously stimulating. We have received an outstanding number of contributions, in terms of quantity and quality, from academics across a wide disciplinary span, both from younger researchers and from the most experienced scholars in the field. We therefore had to redraw the plans for this project a number of times. It quickly became clear (...) to us that the collection would expand beyond the scheduled double issue of the Journal of Consciousness Studies. A triple issue was then drafted, but the number of excellent contributions continued to grow. We therefore had to reconsider the publication plans again, and the decision was made to publish an extended collection of papers in discrete instalments. At present substantial progress has been made towards determining the content of a second double issue of the Journal of Consciousness Studies, due summer 2004. A third instalment now appears to be a real possibility. We welcome enquiries from authors interested in submitting to later instalments, especially those offering a novel perspective that is not otherwise represented. However, we do not intend continue this collection indefinitely. In putting together the first major interdisciplinary collection on this topic, we view our task as that of providing a starting point. Sufficient outlets exist to support ongoing debate. (shrink)

Biology lacks a central organism concept that unambiguously marks the distinction between organism and non-organism because the most important questions about organisms do not depend on this concept. I argue that the two main ways to discover useful biological generalizations about multicellular organization--the study of homology within multicellular lineages and of convergent evolution across lineages in which multicellularity has been independently established--do not require what would have to be a stipulative sharpening of an organism concept.

Karl Marx misappropriated Ferguson's thought even though he championed the Scot's remarks on the division of labor. The argument is developed by examining Marx's specific quotations of Ferguson in literary context and by critiquing Marx's quotations in light of three ethical categories that are implicit in Ferguson's idea of progress. Marx not only presents a highly selective reading of Ferguson and espouses a view of history that is antithetical to Ferguson's idea of progress, but he fails to do justice to (...) the complexity of Ferguson's moral philosophy, even if he viewed the Scot as something of a maverick like himself. (shrink)

It is obvious that technology is rapidly changing the world around us. Nowhere is that change more evident than in the revolution occurring for those with physical and mental limitations-their portrayal in the media, their use of the media to achieve group aims and their use of the new on-line media to communicate with others who have limitations and the non-disabled world. In a very real way the growing sense of community among those with disabilities has been linked to the (...) media. (shrink)